Patent ductus arteriosus
Closure of the ductus arteriosus
Surgical management of patent ductus arteriosus is a management option.
By slow intravenous injection.
Ibuprofen
Ibuprofen 10mg/2ml solution for infusion ampoules
For dose, refer to BNF for Children.
Prescribing Notes:
- Treatment would be under neonatology specialist team.
History Notes
19/06/2023
East Region Formulary content agreed - ERFC 07/06/2023.
Maintenance of the patency of the ductus arteriosus
Dinoprostone
Prostin E2 750micrograms/0.75ml solution for infusion ampoules
For dose, refer to BNF for Children.
Prescribing Notes:
- Dinoprostone is a potent vasodilator, effective in maintaining the patency of the ductus arteriosus whilst awaiting surgery.
- During infusion monitor heart rate, blood pressure, respiratory rate and core body temperature.
- The incidence of adverse effects is dose related. Respiratory depression or apnoea are common in infants less than 2kg. CNS effects such as seizures, pyrexia, irritability and lethargy can occur. Hypotension, nausea, vomiting and diarrhoea are expected common side effects. Rash is a commonly reported side effect in neonates.
History Notes
19/06/2023
East Region Formulary content agreed - ERFC 07/06/2023.