Sinusitis

Treatment of sinusitis

Analgesia, no antibiotic treatment (majority resolve in 14 days) refer to prescribing notes.

Beclometasone
Beclometasone 50micrograms/dose nasal spray

2 sprays every 12 hours into each nostril.

If there is no response after 2 weeks, continue beclometasone and consider antibiotic treatment.

Phenoxymethylpenicillin
Phenoxymethylpenicillin 250mg tablets

500mg every 6 hours for 5 days

Phenoxymethylpenicillin 250mg/5ml oral solution sugar free

500mg every 6 hours for 5 days

If penicillin allergic, prescribe doxycycline.

Doxycycline
Doxycycline 100mg capsules

200mg on day 1, then 100mg daily for 5 days treatment in total

In pregnancy and penicillin allergic.

Erythromycin
Erythromycin 250mg gastro-resistant tablets

500mg every 6 hours for 5 days

Erythromycin ethyl succinate 250mg/5ml oral suspension sugar free

500mg every 6 hours for 5 days

Prescribing Notes:

  • Ensure adequate use of analgesics.
  • Evidence of benefit from nasal saline or nasal decongestants is lacking but may be considered for symptomatic relief.
  • The role of antibiotics in the treatment of sinusitis is controversial.
  • Antibiotics are not recommended for patients who are systemically well, not at risk of complications and symptom duration of less than 10 days. If there is no improvement after 10 days consider delayed antibiotic prescription depending on likelihood of bacterial cause.
  • Consider prescribing an intranasal corticosteroid for people with prolonged or severe symptoms.
  • Antibiotics can be considered for patients with suspected acute bacterial sinusitis when at least three of the following are present (or if the patient is at high risk of complications)
    • discoloured or purulent discharge (with unilateral predominance)
    • severe local pain (with unilateral predominance)
    • a fever greater than 38 degrees Celsius
    • a marked deterioration after an initial milder form of the illness (so-called 'double-sickening')
    • elevated ESR/CRP (although the practicality of this criterion is limited).

History Notes

06/06/2024

Erythromycin ethyl succinate 500mg/5ml oral suspension sugar free discontinued and removed

15/12/2021

East Region Formulary content agreed.

Treatment of sinusitis

Analgesia, no antibiotic treatment (majority resolve in 14 days) refer to prescribing notes.

Children > 12 years consider prescribing high dose nasal corticosteroid.


Beclometasone
Beclometasone 50micrograms/dose nasal spray

See BNFc for dose, duration 14 days.

If there is no response after 2 weeks, continue beclomethasone (if started) and consider antibiotic treatment.


Phenoxymethylpenicillin
Phenoxymethylpenicillin 250mg tablets

For dose and duration see BNFc.

Phenoxymethylpenicillin 125mg/5ml oral solution sugar free

For dose and duration see BNFc.

Phenoxymethylpenicillin 250mg/5ml oral solution sugar free

For dose and duration see BNFc.

If penicillin allergic, prescribe clarithromycin.

Clarithromycin
Clarithromycin 250mg tablets

For dose and duration see BNFc.

Clarithromycin 500mg tablets

For dose and duration see BNFc.

Clarithromycin 125mg/5ml oral suspension

For dose and duration see BNFc.

Clarithromycin 250mg/5ml oral suspension

For dose and duration see BNFc.

If penicillin allergic and > 12 years an alternative is doxycycline.

Doxycycline
Doxycycline 100mg capsules

For dose and duration see BNFc.

If systemically very unwell, symptoms or signs of a more serious illness or condition are present, or there is a high risk of complications, prescribe co-amoxiclav.

Co-amoxiclav
Co-amoxiclav 125mg/31mg/5ml oral suspension sugar free

For dose and duration see BNFc.

Co-amoxiclav 250mg/62mg/5ml oral suspension sugar free

For dose and duration see BNFc.

Co-amoxiclav 250mg/125mg tablets

For dose and duration see BNFc.

Co-amoxiclav 500mg/125mg tablets

For dose and duration see BNFc.

Prescribing Notes:

  • Ensure adequate use of analgesics.
  • Evidence of benefit from nasal saline or nasal decongestants is lacking but may be considered for symptomatic relief.
  • The role of antibiotics in the treatment of sinusitis is controversial.
  • Antibiotics are not recommended for patients who are systemically well, not at risk of complications and symptom duration of less than 10 days. If there is no improvement after 10 days, consider delayed antibiotic prescription depending on likelihood of bacterial cause.
  • Consider prescribing an intranasal corticosteroid for children aged 12 years and over with prolonged or severe symptoms.
  • Antibiotics can be considered for patients with suspected acute bacterial sinusitis when at least three of the following are present (or if the patient is at high risk of complications):
    • discoloured or purulent discharge (with unilateral predominance)
    • severe local pain (with unilateral predominance)
    • a fever greater than 38 degrees Celsius
    • a marked deterioration after an initial milder form of the illness (so-called 'double-sickening')
    • elevated ESR/CRP (although the practicality of this criterion is limited).
  • For more information refer to NICE CKS: Sinusitis.

History Notes

15/01/2024

East Region Formulary content agreed.