Blepharitis

For general guidance on administration of drugs to the eye and on control of microbial contamination of eye drops, please see the ‘General information on eye drops’ recommendations.

NICE CKS: Blepharitis

Treatment of blepharitis

Self-care (see prescribing notes)

Chloramphenicol
Chloramphenicol 1% eye ointment

One application every 12 hours trial for 6 weeks. Frequency and duration of treatment is guided by severity and response to treatment.

If signs of meibomian gland dysfunction or rosacea also a problem

Doxycycline
Doxycycline 100mg capsules

100mg once daily for 2-3 months.

Prescribing Notes:

  • Bathing eyes and increased hygiene may be all that is necessary to treat blepharitis.
  • The eyelid can be cleansed by wetting a cloth with cleanser (for example, baby shampoo diluted 1:10 with warm water) and gently wiping along the lid margins to clear any lid debris.
  • Eyelids should be cleaned twice daily initially, then once daily as symptoms improve.
  • In addition, a warm compress (a clean cloth warmed with hot water) should be applied to closed eyelids for 5-10 minutes once or twice daily; compresses should not be too hot as this may burn the skin.
  • Eyelid hygiene should be continued even when symptoms are well controlled to minimise number and severity of relapses.
  • For posterior blepharitis, a brief gentle eyelid massage following the use of a warm compress can help improve expression of Meibomian gland secretions. Care must be taken to prevent mechanical irritation.
  • Pressure on the eye area should be avoided in people with glaucoma.
  • For further information, see NICE CKS guidance on blepharitis.
  • Cosmetics should be avoided.
  • If hygiene measures are ineffective after 2 weeks offer a trial of chloramphenicol eye ointment.

History Notes

19/06/2023

Update to doxycycline dose, ERWG May 23.

15/12/2021

East Region Formulary content agreed.

Treatment of blepharitis

Self-care (see prescribing notes). Blepharitis in children can be managed by optometrists in the community.

Continue self-care (see prescribing notes) with a trial of antimicrobial eye drops.


Fusidic acid
Fusidic acid 1% modified-release eye drops

See BNFc for dose, duration up to 2 weeks.

Continue self-care (see prescribing notes) with a trial of antimicrobial eye drops.


Chloramphenicol
Chloramphenicol 1% eye ointment

Initial trial to be applied twice daily after lid hygiene for 2-4 weeks. Frequency and duration of treatment is guided by severity and response.

Prescribing Notes:

  • For more information on self-care measures refer to NICE CKS: Blepharitis.
  • Patient information on Blepharitis is available from the NHS and Association of Optometrists.
  • Bathing eyes and increased hygiene may be all that is necessary to treat blepharitis. Cosmetics should be avoided.
  • Watery, intermittently sticky eyes in infants are often due to blocked tear ducts. Massaging the tear duct, eye lids, gently scrubbing off any flakes from the eyelashes and application of a warm compress may be effective.
  • Antibiotics may be indicated if the eye is red or hygiene measures are ineffective after 2 weeks.

History Notes

15/01/2024

East Region Formulary content agreed.