Eye procedures and diagnostics

For general guidance on administration of drugs to the eye and control of microbial contamination of eye drops, please see the ‘General information on eye drops’ section.

Mydriatics for eye examination

Antimuscarinic.

Tropicamide
Minims tropicamide 0.5% eye drops 0.5ml unit dose

Apply 1 drop prior to examination.

Minims tropicamide 1% eye drops 0.5ml unit dose

Apply 1 drop prior to examination.

Phenylephrine + Tropicamide
Mydriasert 5.4mg/0.28mg ophthalmic inserts

One ophthalmic insert per operated eye, a maximum of 2 hours before surgery or the investigative procedure.

Phenylephrine can be used with cyclopentolate or tropicamide.

Cyclopentolate
Cyclopentolate 1% eye drops

Apply 1 drop prior to examination.

Cyclopentolate 1% eye drops 0.5ml unit dose preservative free

Apply 1 drop prior to examination.

Used to supplement the mydriatic effect of the antimuscarinics. Only the 2.5% strength is listed; the 10% strength is rarely used due to transient high blood pressure concerns.

Phenylephrine
Minims phenylephrine hydrochloride 2.5% eye drops 0.5ml unit dose

Apply 1 drop prior to examination.

Prescribing Notes:

  • Antimuscarinics dilate the pupil (mydriasis) and paralyse the ciliary muscle (cycloplegia).
  • Tropicamide is short-acting (4-6 hours) and is a useful mydriatic prior to examining the eye. The BNF advises caution as mydriasis may precipitate acute angle-closure glaucoma in a very few patients who are hypermetropic (long-sighted) and predisposed to the condition because of a shallow anterior chamber. However, the risk is so minimal that this should not be regarded as a contra-indication to its use for diagnostic purposes.
  • All mydriatics can cause blurred vision and patients should be warned not to drive until this has settled (usually after 1-2 hours).
  • All patients having pupil dilation should be advised to seek medical advice if acute pain develops after administration of drops as acute angle-closure glaucoma can occur.
  • Cyclopentolate has a shorter duration of action (up to 24 hours).
  • Phenylephrine may be used to supplement the mydriatic effect of these.
  • Phenylephrine is used as a mydriatic prior to ophthalmic procedures. Its effect lasts up to seven hours.
  • Toxic systemic reactions to atropine and cyclopentolate in the very young and very old are possible.
  • Patients should be warned not to drive for several hours after mydriasis.

History Notes

15/06/2022

East Region Formulary content agreed.

Local anaesthetics
Oxybuprocaine
Minims oxybuprocaine hydrochloride 0.4% eye drops 0.5ml unit dose

1 drop repeated if necessary.

Tetracaine
Minims tetracaine hydrochloride 1% eye drops 0.5ml unit dose

1 drop repeated if necessary.

Proxymetacaine
Minims proxymetacaine 0.5% eye drops 0.5ml unit dose

Apply as required.

Lidocaine + Fluorescein
Minims lidocaine and fluorescein eye drops 0.5ml unit dose

Apply as required.

Prescribing Notes:

  • Oxybuprocaine is the recommended local anaesthetic for use before ophthalmic procedures e.g. tonometry. It has a very rapid onset of action (about 30 seconds).
  • Tetracaine eye drops produce a more profound anaesthesia than oxybuprocaine and are suitable for use before minor surgical procedures. It has a temporary disruptive effect on the corneal epithelium.
  • Local anaesthetic drops should never be used for the symptomatic control of pain because of corneal epithelium toxicity.
  • Proxymetacaine 0.5% eye drops (Minims) cause less initial stinging than oxybuprocaine and is useful in children. May also be used before the instillation of mydriatic/cycloplegic drops for refraction, which sting on instillation.

History Notes

15/06/2022

East Region Formulary content agreed.

Ocular diagnostic stains
Fluorescein
Minims fluorescein sodium 2% eye drops 0.5ml unit dose

Instil one drop as required.

Prescribing Notes:

  • Fluorescein ophthalmic strips are used to detect corneal abrasions/lesions and foreign bodies. They are also used in tonometry.
  • Fluorescein eye drops are usually only used for diagnosis of naso-lachrymal duct patency and leakage of eye wounds.
  • For detection of corneal abrasions, strips are preferred since the drops may not fluoresce properly if too much is instilled into the eye.

History Notes

15/06/2022

East Region Formulary content agreed.

Ocular diagnostics
Apraclonidine
Iopidine 1% eye drops 0.25ml unit dose

Specialist advice.

Prescribing Notes:

  • Apraclonidine 1% eye drops (Iopidine) may be used as a diagnostic test for investigation of possible Horner’s Syndrome. A once only test to be carried out in the eye dept, NOT for ongoing use.

History Notes

15/06/2022

East Region Formulary content agreed.

Mydriatic for eye examination

Antimuscarinic

Tropicamide
Minims tropicamide 0.5% eye drops 0.5ml unit dose

1 drop, 20 minutes before examination

Minims tropicamide 1% eye drops 0.5ml unit dose

1 drop, 20 minutes before examination

Sympathomimetic

Phenylephrine
Minims phenylephrine hydrochloride 2.5% eye drops 0.5ml unit dose

1 drop, 20 minutes before examination

Prescribing Notes:

  • Tropicamide is short-acting (up to 3 hours) and is a useful mydriatic prior to examining the eye. It can cause blurred vision.

History Notes

29/07/2020

Content migrated from LJF website.

Local anaesthetics
Proxymetacaine
Minims proxymetacaine 0.5% eye drops 0.5ml unit dose

1 drop repeated if necessary

Prescribing Notes:

  • Local anaesthetic drops should never be used for the symptomatic control of pain because of corneal epithelium toxicity.
  • Proxymetacaine 0.5% eye drops (Minims) cause less initial stinging and is useful in children e.g. before the instillation of mydriatic/cycloplegic drops for refraction, which sting on instillation.

History Notes

29/07/2020

Content migrated from LJF website.

Ocular diagnostic stains
Fluorescein
Minims fluorescein sodium 1% eye drops 0.5ml unit dose

Instil one drop as required

Minims fluorescein sodium 2% eye drops 0.5ml unit dose

Instil one drop as required

Prescribing Notes:

  • Fluorescein ophthalmic strips are used to detect corneal abrasions/lesions and foreign bodies. They are also used in tonometry. They are also used in tonometry.
  • Fluorescein eye drops are usually only used for diagnosis of naso-lachrymal duct patency and leakage of eye wounds.
  • For detection of corneal abrasions, strips are preferred since the drops may not fluoresce properly if too much is instilled into the eye.

History Notes

29/07/2020

Content migrated from LJF website.